Zhongbo Lab is interested in developing knowledge-based therapies against the human diseases, leukemia and malaria in particular. We investigate the single molecular behaviors in single cells to discover new targets for designing drugs. Currently, a homemade setup of high-resolution magnetic tweezers is our major work horse. The lab members are engineering nucleic acids and proteins to explore the mechanisms of transcriptional regulation in mixed lineage leukemia and the process of malaria invading a red blood cell. The drawing above illustrates some keywords we frequently discuss in our lab.

News (Click for more)

  • Prof. Junhu Chen from CDC of China visited again our lab on 13th Sep, 2016. We updated the malaria project.

  • Prof. Hongbin Li from the University of British Columbia visited our lab on 8th Sep, 2016. He gave a great talk, 'Folding and unfolding dynamics of the metalloprotein Rubredoxin - A single molecule force spectroscopy perspective'.

  • Prof. Chirlmin Joo from TU Delft visited our lab on 9th July, 2016. He gave a fantastic talk, 'Why argonaute is needed to make microRNA target search fast and reliable'.

  • Ning Li will work on the malaria project in the CDC of China in Shanghai from Apr to June, 2016.

  • Open positions

  • We have a project for an undergraduate with programming experience in LabView and MatLab. Please contact Zhongbo for details.

  • We have a project for an undergraduate, examining the interactions between proteins and nucleic acids, please contact Lin Liang for details.

  • For postdoc or graduate student positions, please directly contact Zhongbo.
  • Publications (Click to Pubmed)

    Comming soon.
    We are developing great stories in Nankai.

    People

    Ms. Lin Liang
    Since 2015
    Ms. Kangkang Ma
    Since 2015
    Ms. Ning Li
    Since 2015
    Ms. Xiaofeng Ma
    Since 2015
    Ms. Yanqiu Liu
    Since 2015
    Mr. Guang-Peng Xu
    Since 2016
    Ms. Yueyuan Li
    Since 2016
    Ms. Junli Wang
    Since 2017
    Ms. Yueting Cai
    Since 2017
    Mr. Wei Huang
    Since 2017
    Ms. Lihua Qu
    Since 2017
    Alumni
    Since 2015
    Lab Balitai:1
    Lab Balitai:2
    Lab Balitai:3

    Sponsors

    National Science Foundation of China (Tianjin)

    National Science Foundation of China

    Contact


    Room 421

    The State Key Laboratory of Medicinal Chemical Biology

    Tongyan Rd 32, Tianjin, 300350, China

    Click for map

    Lab workshops (Click for more)

  • LabView core 1, 2, & 3, and MatLab 1 ~ 12

  • Numerical computing with matlab by Cleve Moler

  • Higher Engineering Mathematics 6thEd by J. Bird

  • Molecular Cloning by Green & Sambrook

  • Biophysics for Beginners by Helmut Schiessel

  • Science/Nature Podcast