Zhongbo Lab is interested in developing knowledge-based therapies against the human diseases, leukemia and malaria in particular. We investigate the single molecular behaviors in single cells to discover new targets for designing drugs. Currently, a homemade setup of high-resolution magnetic tweezers is our major work horse. The lab members are engineering nucleic acids and proteins to explore the mechanisms of transcriptional regulation in mixed lineage leukemia and the process of malaria invading a red blood cell. The drawing above illustrates some keywords we frequently discuss in our lab.
Prof. Junhu Chen from CDC of China visited again our lab on 13th Sep, 2016. We updated the malaria project.
Prof. Hongbin Li from the University of British Columbia visited our lab on 8th Sep, 2016. He gave a great talk, 'Folding and unfolding dynamics of the metalloprotein Rubredoxin - A single molecule force spectroscopy perspective'.
Prof. Chirlmin Joo from TU Delft visited our lab on 9th July, 2016. He gave a fantastic talk, 'Why argonaute is needed to make microRNA target search fast and reliable'.
Ning Li will work on the malaria project in the CDC of China in Shanghai from Apr to June, 2016.
We have a project for an undergraduate with programming experience in LabView and MatLab. Please contact Zhongbo for details.
We have a project for an undergraduate, examining the interactions between proteins and nucleic acids, please contact Lin Liang for details.
For postdoc or graduate student positions, please directly contact Zhongbo.