Zhongbo Lab is interested in developing knowledge-based therapies against the human diseases, leukemia and malaria in particular. We investigate the single molecular behaviors in single cells to discover new paradigms of protein-nucleic acids interactions and design new targets for drugs. Currently, a homemade setup of high-resolution magnetic tweezers is our major work horse. The lab members are developing new instruments, employing noval bioconjugate chemistry, and engineering macromolecules to explore the mechanisms of epigenetics in mixed lineage leukemia and the process of malaria invading a red blood cell. The drawing above illustrates some keywords we frequently discuss in our lab.