20: Wang Z, et al. AFM visualized condensation of single human telomeres mediated by TRF1. In preparation. 2025.

19: Wang Z, et al. Nanoscale conformational polymorphism of single human telomeres visualized by AFM. In preparation. 2025.

18: Lu M, et al. The Allosteric Pathways Regulating a Hammerhead Ribozyme. In preparation. 2025.

17: Cao Z, et al. Single-molecule Structural Dynamics of Human DNMT1 Autoactivation. In preparation. 2025.

16: Qin Y, Wu H, Yu Z, Shirinzadeh B, Han J. Development and test of a coarse-fine inverted span-scale dual positioning stage with antagonistic piezo-actuation configuration. Under review. 2025.

15: Gao H, Wang M, Wang Y, Cao Z, Lu M, Zhou J, Jing Y, Zhao Z, Ma K, Wang F, Yu Z. Absolute length distribution of human telomeres at the single-molecule level. Under revision. 2025.

14: Ma K, Yu Z. Quantifying Telomere Length: From Bulk Assays to Single-molecule Resolution. 2025. Just accepted by Biophysics Reports. Available online 2025-03-05. doi: 10.52601/bpr.2025.240068.

13:Liu J, Xiong L, Hu Y, Wang Z, Dai J, Li T, Guo X, Liu R, Yu Z, Li Y, Li Y. Probing Structural Variants of Irregular DNA G-Tracts (N ≤ 2) Using MspA Nanopores. ACS Appl Mater Interfaces. 2025 Feb 20. doi: 10.1021/acsami.4c19806.

12: Lu M, Cao Z, Xiong L, Deng H, Ma K, Liu N, Qin Y, Chen S, Chen J, Li Y, Liu Y, Yu Z. A Hammerhead Ribozyme Selects Mechanically Stable Conformations for Catalysis Against Viral RNA. Communications Biology. 2025 Feb 03; 8(1):165. doi: 10.1038/s42003-025-07600-3.

11:  Gao H, Liu Y, Yu Z. Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers. J Vis Exp. 2024 Aug 30;(210). doi: 10.3791/67251.

10: Nai S, Wang M, Yang J, Ling B, Dong Q, Yang X, Du X, Lu M, Liu L, Yu Z, Chen L. Novel role for Ddx39 in differentiation and telomere length regulation of embryonic stem cells. Cell Death Differ. 2024 Aug 6. doi: 10.1038/s41418-024-01354-x.

9: Ma K, Xiong L, Wang Z, Hu X, Qu L, Zhao X, Li Y, Yu Z. A DNA Force Circuit for Exploring Protein-Protein Interactions at the Single-molecule Level. Chin. J. Chem. 2024 Feb 23; 42(13):1456-1464. DOI:10.1002/cjoc.202300723

Selected by the editor to be the cover story.

8: Zhang Q, Sun T, Yu F, Liu W, Gao J, Chen J, Zheng H, Liu J, Tian W, Su M, Guo Y, Liu X, Pei Y, Wang Z, Chen S, Mu C, Lam SM, Shui G, Li Z, Yu Z, Miao C, Guo H, Lu C, Midgley A, Zhang Y, Chen G, Li C, Bian X, Liao X, Wang Y, Xiong W, Zhu H, Li Y, Chen Q. PAFAH2 suppresses PAF-like phospholipid-mediated synchronized ferroptosis to ameliorate AKI. Nat Chem Biol. 2024 Jan 29. doi: 10.1038/s41589-01528-7.

7: Li, P., Hou, S., Wu, Q., Chen, Y., Wang, B., Ren, H., Wang, J., Zhai, Z., Yu, Z., Lambert, C. J., Jia, C., & Guo, X. (2023). The role of halogens in Au-S bond cleavage for energy-differentiated catalysis at the single-bond limit. Nature communications, 14(1), 7695. https://doi.org/10.1038/s41467-023-43639-8.

Highlighted by Christian Kuttner, the editor of Nature communications, as Featured articles in Inorganic and physical chemistry.

6: Wang Z, Cao Z, Ma K, Lu M, Wang M, Gao H, Gong D, Liang L, Yu Z. Reading Time and DNA Sequence Preference of TET3 CXXC Domain Revealed by Single-Molecule Profiling. Chin. J. Chem. 2023 Feb 08; 41(10), 1177-1184. DOI: 10.1002/cjoc.202200780. 

Selected by the editor to be the back cover story.

5: Liang L, Ma K, Wang Z, Janissen R, Yu Z. Dynamics and Inhibition of MLL1 CXXC Domain on DNA Revealed by Single-Molecule Quantification. Biophys J. 2021 Aug 17; 120(16):3283-3291. doi: 10.1016/j.bpj.2021.03.045. 

NEW AND NOTABLE | Biophysical Journal

Profiling selective binding to promoter CpG islands: a novel application of single-DNA mechanical footprinting assay

Wenmao Huang, Jie Yan

Published: Aug 17, 2021 DOI: 10.1016/j.bpj.2021.07.010

4: Liang L, Wang Z, Qu L, Huang W, Guo S, Guan X, Zhang W, Sun F, Yuan H, Zou H, Liu H, Yu Z. Single-molecule multiplexed profiling of protein-DNA complexes using Magnetic Tweezers. J Biol Chem. 2021 Jan-Jun; 296:100327. doi: 10.1016/j.jbc.2021.100327. 

3: Li X, Wang M, Zheng W, Huang W, Wang Z, Jin K, Liu L, Yu Z. Dynamics of TRF1 organizing a single human telomere. Nucleic Acids Res. 2021 Jan 25; 49(2):760-775. doi: 10.1093/nar/gkaa1222. 

2: Ma X, Zhu M, Liu J, Li X, Qu L, Liang L, Huang W, Wang J, Li N, Chen JH, Zhang W, Yu Z. Interactions between PHD3-Bromo of MLL1 and H3K4me3 Revealed by Single-Molecule Magnetic Tweezers in a Parallel DNA Circuit. Bioconjug Chem. 2019 Dec 18; 30(12):2998-3006. doi: 10.1021/acs.bioconjchem.9b00665.

1: Li N, Wang J, Ma K, Liang L, Mi L, Huang W, Ma X, Wang Z, Zheng W, Xu L, Chen JH, Yu Z. The dynamics of forming a triplex in an artificial telomere inferred by DNA mechanics. Nucleic Acids Res. 2019 Sep 5;47(15):e86. doi: 10.1093/nar/gkz464.

State key laboratory of precision measuring technology and instruments (Tianjin University) 

National Natural Science Foundation of China (Tianjin)

National Natural Science Foundation of China